omentin-1 rs2274907 and resistin rs1862513 polymorphisms influence genetic susceptibility to nonalcoholic fatty liver disease

nonalcoholic fatty liver disease (nafld) is an obesity-associated disease and dysregulation of adipokines has an important role in its development. omentin-1 (itln1 protein) and resistin are two adipokine secreted from adipose tissue. single nucleotide polymorphisms in the adipokine genes may affect expression and activity of the adipokine, and thus play a contributory role in nafld pathogenesis. the aim of the present study was to investigate the association between omentin-1 rs2274907 (326a/t) and resistin rs1862513 (-420 c/g) polymorphisms and risk of nafld in iranian patients. this case-control study was done on 282 subjects included 94 patients with nafld and 188 healthy peoples. the genotypes were determined using pcr-rflp method. the frequency of omentin-1 at genotype in patients with nafld was significantly different from that in the control (or=2.3, 95% ci: 1.3-3.8, p=0.003). a significant association was observed between nafld and the gg genotype regarding resistin rs1862513 polymorphism (or=2.3, 95% ci: 1.1-4.8, p=0.03). in conclusion, omentin-1 rs2274907 and resistin rs1862513 polymorphisms might be a candidate genetic factor for susceptibility to nafld.